Memory Issues, Vitamin D and Chronic Fatigue Syndrome

I tend to view some of the processes involved with CFS to parallel (but are not identical) to Alzheimer’s Disease. Memory issues with CFS can remit with remission, AD has no remission.

Recently, the role of vitamin D with AD has had some research published (Journal Neurology, August 6, 2014). Low or very low Vitamin D levels double the risk of AD.  CFS research has found that the severity of symptoms increases with low levels of vitamin D and greatly reduce when patients are at the top of the recommended range (or slightly beyond).

One form of vitamin D, 1,25D (not normally tested for) appears to go up or down depending on severity of CFS symptoms.  By up, I mean very far above the normal range. When the lab did their first test of my 1,25 levels, it was so high they assumed a lab error. They repeated the test with the same result. With remission, I dropped down to the normal range of 1,25D.

A few years ago, there was a fad treatment, the Marshall Protocol, that promised remission if you pushed your Vitamin D level down to zero.  Bad idea. I know many people who tried it that are still addressing side-effects that arose during their attempt to do this protocol (under MD supervision).

And many many more!

 

How much, technically that needs to be done in consultation with your MD.  Most MDs will just want to get people into the bottom of the normal range. My physician wanted me to be near the top of the normal range. How much was I taking, around 20,000 IU of Vitamin D3 per day (as you get older, it takes more to maintain a level).

 

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Memory problems with Chronic Fatigue Syndrome

While I had active CFS, I had a SPECT scan. The radiologist read the abnormal results as early Alzheimer. “Early” does not mean starting, but before the typical age of onset. At the same time, I was having severe memory issues (since disappeared).

In a recent New Scientist article, , I read how anti-tumor necrosis factor-α (TNF-α) was being used successfully for slowing the progress of Alzheimer’s Disease.  I was not surprise because I was talking several anti-TNF-α supplements as part of my research approach.

On the flip side, some foods like honey [2003] increases TNF.

Also, in my series on Crohn’s disease, many of the supplements listed were known to reduce TNF .

So if you have memory problems, you may wish to increase your anti-tnf supplements (and make sure that you check all of them to see if any increases TNF )

Chronic Fatigue Syndrome and Myeloma

A reader has both diagnosis and asked me about any relationships and the complexities of treating both concurrently. I’m not a MD, but I am a tolerable researcher.

Co-Morbid Instances

My first observation is that getting numbers may be challenging because a myeloma diagnosis may disqualify many people from getting a CFS diagnosis. If the MD attributes some of the CFS symptoms to myeloma — then the CFS diagnosis cannot be done with the research definition (see symptoms in red below).

Myeloma impacts red blood cells which can result in low oxygen delivery which will cascade into symptoms also seen with hypercoagulation and thus CFS.

“Some problems (e.g., weaknessconfusion and fatigue) may be due to anemia or hypercalcemiaHeadache, visual changes and retinopathy may be the result of hyperviscosity of the blood depending on the properties of the paraprotein. Finally, there may be radicular pain, loss of bowel or bladder control (due to involvement of spinal cord leading to cord compression) or carpal tunnel syndrome and other neuropathies(due to infiltration of peripheral nerves by amyloid). It may give rise to paraplegia in late presenting cases.” From Wikipedia

WebMd says “Multiple myeloma is a blood disorder related to lymphoma and leukemia, because it usually arises in the bone marrow. There is no cure for multiple myeloma, but treatments are available that slow its progression.”

There is an increased risk of cancer with CFS,  CFS-Ireland gives a nice list of studies, and the original Incline Village outbreak had a high incidence of cancer.

Mechanism?

We know that many cancers are associated with a virus, we also know that virus can alter gut bacteria (effectively farm it to support the virus). There has not been (that I could find) a specific virus associated with Myeloma.

At this point, if you have an apparent double diagnosis I would suggest trying to verify that CFS is likely, to do this, I would strongly recommend:

  • A SPECT (not MRI) scan — which should show major issues in 80% of cases
  • A Microbiome analysis — which should show almost no E.Coli and the typical shifts seen with CFS
  • Vitamin 1-25 (not the regular Vitamin D) – which should show very high levels

If you are not positive on at least 2 of the above 3, then the CFS diagnosis is probably (95%) false.

 

 

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