A Probiotic advertising as helping CFS

A reader forwarded me a link to  Probiozym (in the US and Canada, it is called HLC Mindlinx). He indicated that he has heard that people are reporting an improvement from it. With CFS, I tend to be wary of “reported improvements” over the social networks — too often it turns out to be a placebo effect. I actually like placebo effects because often they reduce stress in the individual (which helps ameliorate symptoms).

So the key questions about this new offering should be:

  • Is there any objective evidence that it may be effective?
  • If the cost is above the price of “equivalent probiotics” is the premium warranted?

What is in this probiotic?

The product was developed in Norway. Unlike many probiotic manufacturers, they are open about the contents:

  • Lactobacillus rhamnosus NEU 427 50.0 mg
  • Lactobacillus crispatus NEU 458     50.0 mg
  • Lactobacillus acidophilus     50.0 mg
  • Bifidobacterium bifidum      2.5 mg
  • Fructooligosaccharides (FOS)          137,5 mg

On first look, it should help because it contains Bifidobacterium bifidum as cited in earlier posts [1],[2]. There is a species that I have not seen before, Lactobacillus crispatus. This and Lactobacillus Jensenii are predominant species found in the female lower genital tract. 13% of the genome is novel and not found in other species. It is considered to be one of the strongest H2O2-producing Lactobacilli.

Object Evidence

I found no PubMed articles on this probiotic (either name). There was nothing for either of the strains cited (NEU 427 or NEU 458). I focused on Lactobacillus crispatus and found no studies for the usual IBS, CFS, etc. All of the trials were treatment with bacterial vaginosis.

Cost Effectiveness

I found it on Amazon.com at $40 for 60 capsules which is comparable to the pricing of Align. IMHO, pricing is reasonable. Pricing is better than Seroyal Gammadyn Mn-Cu 30 Unidoses which contains only Lactobacillus crispatus (unknown dosage).

Summary

My reading on Lactobacillus Crispatus suggests that it is definitely worth a try — while I tend not to be favorable to Lactobacillus acidophilus containing probiotics — balancing everything, there is more likelihood for positive than negative consequences. A key factor is that it is a major hydrogen peroxide producer.

Unlike Lactobacillus case  and Lactobacillus delbrueckii subsp. bulgaricus (common in yogurts) which are histamine producers this appears to be low producers.

New Insight to Crohn’s and possibly Histamine Intolerance and CFS

A recent article, J. Pickard et al., “Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness,Nature, doi:10.1038/nature13823, 2014. with summary on TheScientist found that the sugar fucose  (yes, that is the correct spelling!) may play a major role. TheScientist article title says it well ‘Supporting the “Good” Gut Microbes During systemic infection, mice kick-start the production of a specific sugar to feed and protect the beneficial bacteria in their guts while fighting pathogenic strains.’

  • Chervonsky now wants to see how important this fucosylation pathway may be in humans. “About 20 percent of the population is missing the Fut2 gene, and this has been linked to Crohn’s disease.”
  • If you have done 23AndMe.com (which I would strongly recommend to any suffers from the above — it costs just $99 and allows you to see if new discoveries, like the Fut2 gene, is a factor for you). Fut2 is connected with Norovirus (aka Cruise Ship Sickness) resistance.

For the bio-Nerds:
“The fractionated fucoidan, especially the F1 fraction, strongly stimulated murine macrophages (Raw 264.7 cells), producing a considerable amount of nitric oxide (NO) and inducing expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and interleukin-10 (IL-10) transcripts by activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) pathways.” [2014] almost all of which are significant for CFS.

Screen Shot 2014-10-02 at 10.48.14 PM

We also found a 2001 study reports found that fucose “significantly and dose-dependently inhibited the histamine release induced

Availability: Looking around on the internet, there appear to be sources for fucose — but at an unreasonable $100 for 1 g :-( – until you hit Alibaba, http://www.alibaba.com/showroom/fucose.html (Yes, I know it’s China — but the reality is that a lot of supplements you take are made there… at $1 for 2 lbs from some suppliers) There are more suppliers at http://www.chemicalregister.com/D-_+_-FUCOSE/Suppliers/pid93488.htm

  • Dosage – unknown I suspect < 1/8 teaspoon
  • Safety – no human trials that I could find. Material Safety Sheet provides little information.

My old Web Site from my 2nd CFS episode (2 years) and remission

This site was capture by a friend as a PDF and thus can be made available to you. Much of the information has been updated — but there are a lot of good links still in it — plus you can read my monthly logs as I worked thru CFS to remissions

  • idefx – my 1999-2001 trek to remission from CFS
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