Fermented Mushroom Extract

A reader sent this to me:

“This is another supplement [Active hexose correlated compound (AHCC) – a fermented mushroom extract] that helped me a lot and stopped working

Since I am working off a model, it gives a framework to evaluate such things and possibly identify the mechanisms involved. Fermentation often produce bacteria that produces antibiotics [In fact, I just heard a report that 25% of the bacteria in men’s beard produce antibiotics!!!].

Reading PubMed, the mechanism of AHCC effects is not clear, but what we do find in terms of results include:

  • “the oral treatment with AHCC protected mice from lethal infection with Pseudomonas aeruginosa and intraperitoneal one also protected mice from infection with methicillin-resistant Staphylococcus aureus (MRSA).”[2000]
  • “Supplementation with AHCC appears to modulate immunity and increase survival in response to acute infection and warrants further investigation.” [2008]
  • ” Our previous studies demonstrated that heat-shock protein 27 (HSP27) was involved in …. and it was down-regulated by AHCC-treatment.”[2015]
  • adenosine was identified as one of the NO suppressive components in AHCC” [2014]
    • “Herein we describe the synthesis and evaluation of a series of adenosine analogs for in vitro antibacterial activity against Staphylococcus aureus … compound c6 has much stronger antibacterial potency against Pseudomonas aeruginosa than ciprofloxacin” [2015]
  • “Our data provide a preclinical experimental basis for the synergistic effect of AHCC and B. longum BB536 on inflammatory bowel disease.” [2013]
  • “The study of colonic microflora indicated that rats treated with AHCC had higher aerobic and lactic acid bacteria counts as well as higher bifidobacteria counts,” [2007]

The heat shock protein rang a bell, and checking Wikipedia we find “Production of high levels of heat shock proteins can also be triggered by exposure to different kinds of environmental stress conditions, such as infection, inflammation, exercise, exposure of the cell to toxins” Heat shock proteins are associated with CFS [2012] ” Basal hsp27 was significantly higher among CFS patients compared to controls, and decreased immediately post-exercise, remaining below basal levels even at 7 days” [2002] and even Cort Johnson has a post on them. The gotcha is that it appears to be seen in only 30-40% of CFS patients (which suggests that it maybe microbiome dysfunction centric).

Bottom Line

It is a prebiotic that does influence bacteria growth. It appears to have antibiotic characteristics against a significant species for CFS. It also impacts heat shock proteins and appears to reduce chemicals produced by stress.

The reader’s report of it stop working is reasonable, because bacteria such as staphylococcus aureus would originally be reduced significantly and then the resistant strains would re-populate. A strong reason to do rotation with only 1-2 weeks on anything that had antibiotic characteristics.

If you take it, it should be taken with B.longum and other bifidobacteria probiotics.

Free Notes in English, French, Spanish, German

In 2012, I started working on notes on CFS as part of searching for the best path forward. I attached the book as a PDF to this page, for people to use for reference.

I also attached mechanical translations into

You will find about 90 pages and 1000 references to PubMed.

Och Svenske!

Enjoy!

What are common symptoms of CFS?

I am a numbers man. Many studies say something like “CFS have high A-B-C” which is correct if you look at the average of a group. Unfortunately, it may just be 30% of the patients that are high and 70% that are normal. I have attempted to track down abnormality by the percentage of patients with various conditions.

  • Magnesium deficiency 45% – 50% of CFS patients have low levels [2000]
  • CoQ 10 low in 45% of CFS patients have low levels [2009]
  • high levels of cytokines in 60% only, 40% of CFS patients do not have high levels of the typical 9 cytokines [1994].
  • Cortisol is low in 33% [2001]
  • Heart is smaller [2011] (61% [2008])
  • Iron – 69% of CFS patients are insufficient or deficient [2001] [2011].
  • Magnetic resonance imaging (MRI) studies are hit-and-miss for showing abnormalities [1997] [2000] [2010].  Approximately 27% [1993] – 32%[1997] has abnormal scans.
  • Positron emission tomography (PET) scan has 50% with abnormal scans [2003]
  • Single-photon emission computerized tomography (SPECT) scans has 80% – 81% with abnormal scans [1992] [1994]
  • Shortness of breath (32%)
  • Dyspnea on effort (28%),
  • Rapid heartbeat or tachycardia (18% – 38%),
  • Chest pain (43%)
  • Neurally-mediated syncope (21%)
  • Fainting (43%),
  • Orthostatic dizziness (40% – 45%)
  • Coldness of feet (42%), were all frequent complaints.
  • Hypo-tension (28%) was occasionally noted.
  • Electrocardiograms with right axis deviation (21%) and
  • Severe sinus arrhythmia (34%)
  • Small heart shadow (cardiothoracic ratio <or=42%) patients (60%)
  • Low heart stroke volume (36%)

Infections found with Percentages

There are many other infections found that are over-represented with CFS compared to controls.

“A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome.” [2006]

  • Q fever confirmed – 17%  [2006]
  • Ross River virus – 24%  [2006]
  • EBV (20%[2003] -23% [1991] – 27% [2006] – 57% [2004]) Epstein-Bar Virus (EBV)
  • Mycoplasma (50%[2003] – 52%[2003] – 69% [2004] [1998])
  • HHV6 (31% [2003]) Human Herpes Virus 6 (HHV6)

Bottom Line

The model that is the simplest to explain the same type symptoms across many infection is a stable dysfunctional microbiome. The precise symptoms are dependent on the specific bacteria involved. These bacteria are more varied and unique than DNA. High or low values are likely caused by specific groups of bacterias.

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