New Probiotic on Market: L Reuteri NCIMB 30242 (ONLY)

There are eight PubMed studies on this strain.

  • Significantly changes ehe size and composition of the circulating bile acid [2015
  • a greater proportion of L. reuteri-treated subjects showed improved general GI health status (p = 0.042) and improved diarrhea symptoms (p = 0.03). [2013]]
  • the first report of increased circulating 25-hydroxyvitamin D in response to oral probiotic supplementation[2013]

For general information about L.Reuteri see my earlier post.

Available from manufacturer and on Amazon .

I have just ordered some myself.

Probiotics with Demonstrated Health Benefits and Other Gems

Tonight I found two gems that I wish to share

“The major effects of stress on gut physiology include:

  1. alterations in gastrointestinal motility;
  2. increase in visceral perception;
  3. changes in gastrointestinal secretion;
  4. increase in intestinal permeability;
  5. negative effects on regenerative capacity of gastrointestinal mucosa and mucosal blood flow; and
  6. negative effects on intestinal microbiota.

Mast cells (MC) are important effectors of brain-gut axis that translate the stress signals into the release of a wide range of neurotransmitters and proinflammatory cytokines,”[2011]

Histamine released from Mast Cells cause many of the symptoms of a Jarisch-Herxheimer reaction. So I was about to do a quick review of PubMed for candidates that reduced Mast Cell release:

  • Lactobacillus GG (LGG) [2014] – strong impact – Commercial Probiotic: Culturelle
  • L. salivarius HMI001 [2012]
  • L. casei Shirota (LCS)  [2012]
  • Lactobacillus plantarum depends on the specific strain — if not known, avoid
    • LS/07 CCM7766 [2015] – moderate impact
    • L. plantarum WCFS1 – INCREASES Mast Cell release [2012]

At this point of browsing PubMed, I discovered the 2014 article (World J Gastroenterol. 2014 Aug 28; 20(32): 11023–11032.) and it distracted me because it had some nice tables based on recent literature which warrants reposting.

Recommendations for probiotic use from [2014]

Clinical condition Effectiveness Organism

Diarrhea

Infectious-adult-treatment A Saccharomyces boulardi, LGG
Infectious-childhood- treatment A LGG. Lactobacillus reuteri
Prevention of infection B S. boulardii, LGG
Prevention of AAD A S. boulardii, LGG, L. casei, L. bulgaricus, S. thermophilus
Treatment of recurrent CDAD B S. boulardii, LGG
Prevention of CDAD B LGG, S. boulardii
IBD

Pouchitis

Preventing and maintaining remission A VSL#3
Induce remission C VSL#3

Ulcerative colitis

Inducing remission C Escherichia coli Nissle, VSL#3
Maintenance C E. coli Nissle, VSL#3
Crohn’s C E. coli Nissle, S. boulardii, LGG

IBS

B Bifidobacterium infantis
IBS C Bifidobacterium animalis, VSL#3, Lactobacillus plantarum
Immune response A LGG, Lactobacillus acidophilus, L. plantarum, Bifidobacterium lactis, Lactobacillus johnsonii

Allergy

Atopic eczema assoc. with cow milk allergy
Treatment A LGG, B. lactis
Prevention A LGG, B. lactis
Radiation enteritis C VSL#3, L. acidophilus
Vaginosis and vaginitis C L. acidophilus, LGG, L. reuteri

Reproduced with permission from reference Floch et al[31].

  • An ‘‘A’’ recommendation is based on strong, positive, well-conducted, controlled studies in the primary literature, not abstract form;
  • A ’‘B’’ recommendation is based on positive, controlled studies but the presence of some negative studies;
  • A ‘‘C’’ recommendation is based on some positive studies.
  • IBD: Inflammatory bowel disease;
  • LGG: Lactobacillus GG;
  • S. boulardii: Saccharomyces boulardii.

Reflections on the Treatment of Histamine Oversensitivity

I have an ongoing interest in this area, and this is a followup to my Jan 20th post dealing with Histamine Producing Bacteria and their treatment. In that article I found that Cinnamon, Clove, Sage were good candidates for reducing Proteus morganii  (All species) which is likely an overgrowth in sensitive individuals (To confirm that, we will need a population of histamine-sensitive people getting their gut bacteria sequence).

When I did from googling on those and histamines, I found that they were frequently referred to as histamine liberators [Amy Burkhart, M.D.]. That description is probably very correct — the histamine is being released from dead and dying Proteus morganii.

Unfortunately, some cases writers deem them to be histamine producers [ref, ref] which clouds the issue for sufferers and may prevent them from being released from this problem!

Die-Off or the Jarisch-Herxheimer reaction

Wikipedia has a good summary of the “Herx”. I have experienced this on several occasions and actually view it as an indicator that I am taking an effective herb, spice or antibiotic for what was making me sick. The Herx stopped with remission. By moderating the dosage, I could tune the herx to last only a few hours (or at night, all night long) – with the result that after the herx ended, I felt better.

  • “plasma histamine concentrations rose appreciably before and during the clinical phase of the reaction.”[1985 Full Text]

So the question then becomes one of moderating the histamine release. I recently came across G. Pelletier’s “Naturally Occurring Antihistamines in Body Tissue” in Histamine II and Anti-Histaminics Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology Volume 18 / 2, 1978, pp 369-380

He found that arginine – an amino acid, had significant impact and was the easiest to obtained of items listed. Interestingly, I found that arginine was usually associated with histamine in most online patient-written articles and recommended to be avoided. In other articles, I found that histidine and arginine tend to bind to each other (potentially reducing the risk of histidine being converted to histamine?). Going to PubMed, I found

  • “Our findings reveal that malarial-parasite-infected mice, like humans, develop L-arginine deficiency, which is associated with intestinal mastocytosis, elevated levels of histamine, and enhanced intestinal permeability.” [2013], so arginine deficiency and elevated histamine appears associated. And supplementation can reduce it.
  • Arginine and glutamine attenuate IgE-dependent human mast cell activation” [2013]
  • “while the histamine response in cells cultured in a high Arginine concentration was suppressed” [2013]
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