This is a follow up to my earlier post: Sudden Onset ME Flare – uBiome One Week Later The purpose of this series is to gain insight on what happens during the early stages of Myalgic encephalomyelitis/chronic fatigue syndrome . A ME diagnosis takes at least 6 months after onset to get usually. In my case, I have been down the full route and I know the early symptoms (which allows rapid intervention).
Ubiome Results
Reports Showing Changes.
There was some improvement over the two weeks, but the lost of microbiome function continued in other areas. This is not unexpected because the microbiome state is a cascade of microbiome changes that takes time to resolve (a Markovian chain to any geeks reading this).
Good News 🙂
Bad News 😦
This is likely good news…..
Reports with no change
Production of Vitamin K and Vitamin B9 — still at Zero: Supplement time!
Yogurt has no effect
Despite a liter of yogurt each day — no effect
Microbiome Prescription Site
Over on this site, our news is different from ubiome.
Bacteria Pattern matching conditions
The number of high bacteria associated with known conditions dropped back to almost my prior levels from a year ago. The number of low bacteria associated dropped significantly.
The associated conditions with the most significant drops are shown below:
End Products
In terms of End Products, a number of significant shifts (remember this is an experimental report)
- INCREASE in:
- 5-hydroxytryptamine (Serotonin)
Acetylcholine
Bacteriocins (natural antibiotics)
betaine
Biogenic amines
Cobalamin (Vitamin B12)
D-Galactose
D-lactate - Endocannabinoids
Fucose
Lactic acid
Urolithins
- 5-hydroxytryptamine (Serotonin)
- DROP in:
- 3,4-Dihydroxyphenylacetic acid
- Bicarbonate (to zero)
- Methane
Bacteria Shifts
Remember that there are no ‘norm’, I have the left 2 columns from being in a full (symptomless) remission and the right 2 are from this flare.
At the Genus level,
- low Staphylococcus is a concern (0,0 -> -98%, -98%)
- low Anaerococcus also (0,0, -> -45%, – 65%)
Bottom Line
I will be doing another uBiome next week. Overall, I am positive.
- I am up to 2 – 3 hrs/sessions with a break between for work (i.e. 75% time), using vacation time to keep me at full pay check.
- Compare to my usual work day (3 hr of commute + 8hrs, I am at 55% of normal)
- I have tried pressing to a 4 hr session once or twice a week, I can really feel it the next day — so 3 hr work-sessions is my safe zone.
- Once a week, I do an ‘outing probe’ – that is drive or driven for a hour, then meet with friends for a few hours then head home.
- Still have ‘day after payback’:
- often with depression,
- impaired cognitive function for the following day — which clears by the second day.
- sleep pattern disturbances
- This probe helps me keep real with the actual state of recovery (i.e. work from home is fine, a commute to work would worsen the situation).
- Still have ‘day after payback’:
Two Approaches to suggestions
The normal approach is to upload the ubiome.json to the analysis site and see the suggestions. After doing the above analysis, I can get suggestions based solely on the areas of my concern:
- low Staphylococcus
- low Anaerococcus
- low Fibrobacter
by going to the All Bacteria [Genus] Reported page and just entering those 3. This approach excludes the shifts from population norms, which may be natural shifts (due to DNA) for me. For example, Fibrobacter only occurs in 30% of people — but it was there always prior to this flare — so it’s loss is likely significant .The results are shown below — and very interesting
Looking at probiotics only:
Using the full set of bacteria:
CFS Remission 